SIEF participation


All manufacturers and importers that have pre-registered a substance by 1 December 2008 are born members of a Substance Information Exchange Forum (SIEF).

Pre-SIEF and SIEF
The pre-SIEF shall ensure agreement on the identity of the substance(s). The SIEF aims to facilitate the exchange of hazard data and agreement on classification and labelling of the substance.

A SIEF member may have the following roles:

  • Leading: member with a strong market position and available resources to lead and drive registration to completion
  • Involved: member with intention to register and interest to participate in the dossier creation process
  • Passive: member with intention to register but with limited resources or interest to actively participate in the discussions
  • Dormant: member with no intention to register

DHI assists SIEF members in fulfilling their role at a level matching their needs. Our technical services include:

  • Third party representative
  • Assessment of relevance, quality and costs of studies
  • Development of testing strategy
  • Grouping of substances, read-across, QSAR, exposure based waiving 
  • Application of the weight of evidence approach
  • Classification and labelling 
  • Exposure assessment and exposure scenario generation
  • Preparation of extended SDS
  • Perform or facilitate test studies